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. 2018 Sep 27;9:454. doi: 10.3389/fpsyt.2018.00454

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Copyright © 2018 Li, Hou, Wang, Jia, Qin and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Static (A,B) and dynamic (C) metabolomics analyses of the fecal metabolomes collected in the 5th week of CUMS modeling. S-Plot (A) and OPLS-DA plot (B) were used to visualize the static metabolomics analysis. Metabolites with VIP>1 and p < 0.05 were considered to be differential metabolites. Only propionic acid was labeled in the S-plot; please refer to Table 1 for detailed information on all differential metabolites identified via the static metabolomics analysis. ASCA (C) was used to analyze in the dynamic metabolomics data. Metabolites with a high leverage value and a low SPE value were considered to be differential metabolites (the well-modeled group); please refer to Table 2 for detailed information on all of the differential metabolites identified via ASCA dynamic metabolomics analysis.