Table 1.
Selected characteristics of incident cases of esophageal cancer and their matched controls in each cohort study
| Characteristics Matching Variables |
ACS CPS-II NC Cohort | PLCO Cohort | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Cases N= 51 |
Controls N= 153 |
p | Cases N= 74 |
Controls N = 219 |
p | |
|
| ||||||
| Age at mouthwash collection; mean (SD) | 71.4 (6.1) | 71.4 (6.0) | 0.97 | 65.2 (5.6) | 65.3 (5.5) | 0.82 |
|
| ||||||
| Months from mouthwash collection to Dx; mean (SD) | 35.3 (24.5) | 35.3 (24.3) | 1.00 | 52.6 (30.1) | 53.3 (29.9) | 0.85 |
|
| ||||||
| Gender; n % | 1.00 | 0.97 | ||||
| Female | 8 (15.7) | 24 (15.7) | 15 (20.3) | 44 (20.1) | ||
| Male | 43 (84.3) | 129 (84.3) | 59 (79.7) | 175 (79.9) | ||
|
| ||||||
| Race/Ethnicity; n % | 1.00 | 0.99 | ||||
| Caucasian | 50 (98.0) | 150 (98.0) | 67 (90.5) | 198 (90.4) | ||
| African-American/Other | 1 (2.0) | 3 (2.0) | 7 (9.5) | 21 (9.6) | ||
|
| ||||||
| Unmatched Variables | ||||||
|
| ||||||
| BMI group (kg/m2); n (%) | 0.38 | 0.89 | ||||
| < 25 | 22 (43.1) | 50 (32.7) | 18 (24.3) | 55 (25.1) | ||
| 25–29.9 | 18 (35.3) | 63 (41.2) | 37 (50.0) | 113 (51.6) | ||
| ≥ 30 | 5 (9.8) | 26 (17.0) | 17 (23.0) | 48 (21.9) | ||
| Missing | 6 (11.8) | 14 (9.1) | 2 (2.7) | 3 (1.4) | ||
|
| ||||||
| Smoking status; n (%) | 0.01 | 0.01 | ||||
| Never | 11 (21.6) | 60 (39.2) | 20 (27.0) | 99 (45.2) | ||
| Former | 32 (62.7) | 86 (56.2) | 44 (59.5) | 108 (49.3) | ||
| Current | 8 (15.7) | 7 (4.6) | 10 (13.5) | 12 (5.5) | ||
|
| ||||||
| Pack-years, former and current smokers; mean (SD) | 31.5 (26.7) | 31.9 (31.9) | 0.94 | 54.0 (30.4) | 36.2 (28.3) | 0.0002 |
|
| ||||||
| Alcohol consumption; n (%) | ||||||
| None | 16 (31.4) | 55 (35.9) | 0.55 | 23 (31.1) | 73 (33.3) | 0.72 |
| Drinker | 35 (68.6) | 98 (64.1) | 51 (68.9) | 146 (66.7) | ||
| Drinks/week; median (IQR) | 5.7 (2.1 – 18.1) | 3.4 (1.0 – 9.1) | 0.10 | 5.8 (1.1 – 14.6) | 2.4 (1.1 – 7.0) | 0.13 |
|
| ||||||
| Education; n % | 0.94 | 0.41 | ||||
| <12 grade | 3 (5.9) | 12 (7.8) | 2 (2.7) | 17 (7.8) | ||
| High School/Vocational | 15 (29.4) | 39 (25.5) | 30 (40.5) | 77 (35.2) | ||
| Some College | 10 (19.6) | 33 (21.5) | 10 (13.5) | 38 (17.4) | ||
| College Graduate | 10 (19.6) | 29 (19.0) | 13 (17.6) | 39 (17.8) | ||
| Graduate Degree | 12 (23.5) | 39 (25.5) | 18 (24.3) | 48 (21.9) | ||
| Missing | 1 (2.0) | 1 (0.7) | 1 (1.4) | - | ||
|
| ||||||
| Marital Status; n % | 0.48 | 0.85 | ||||
| Married | 40 (78.4) | 113 (73.9) | 60 (81.1) | 175 (79.9) | ||
| Separated/Divorced | - | 2 (1.3) | 7 (9.5) | 20 (9.1) | ||
| Widowed | 2 (3.9) | 12 (7.8) | 4 (5.4) | 18 (8.2) | ||
| Never Married | - | - | 2 (2.7) | 6 (2.7) | ||
| Missing | 9 (17.6) | 26 (17.0) | 1 (1.4) | - | ||
|
| ||||||
| Tumor Histology; n (%) | ||||||
| Adenocarcinoma | 31 (60.8) | N/A | 49 (66.2) | N/A | ||
| Squamous cell carcinoma | 12 (23.5) | N/A | 16 (21.6) | N/A | ||
| Other | 8 (15.7) | N/A | 9 (12.2) | N/A | ||
BMI – body mass index, SD – standard deviation, IQR – inter-quartile range