Table 3.

Associations of beta and gamma HPV species and types with risk of esophageal cancer

Beta HPV Species†	Cases (n=125)		Controls (n= 372)		Adjusted Model*			Permutated Pξ
	N	%	N	%	OR*	95% CI	p
Any Beta HPV	81	64.8	205	55.1	1.57	1.00 – 2.47	0.048	0.538
Any Beta1 HPV	59	47.2	146	39.3	1.49	0.96 – 2.31	0.08	0.716
Any Beta2 HPV	64	51.2	160	43.0	1.34	0.88 – 2.05	0.17	0.951
Any Beta3 HPV	24	19.2	60	16.1	1.26	0.73 – 2.18	0.41	>0.999
Specific Beta HPV Types†
Beta1 HPV5	22	17.6	42	11.3	1.75	0.97 – 3.16	0.07	0.655
Beta1 HPV12	11	8.8	27	7.3	1.24	0.58 – 2.65	0.58	>0.999
Beta1 HPV20	22	17.6	46	12.4	1.53	0.87 – 2.70	0.14	0.908
Beta1 HPV36	15	12.0	33	8.9	1.20	0.61 – 2.35	0.60	>0.999
Clade of Beta1 HPVs 5, 36, 47, & 143	26	20.8	59	15.9	1.34	0.79 – 2.27	0.28	0.995
Beta1 HPV105	14	11.2	29	7.8	1.31	0.65 – 2.63	0.45	>0.999
Beta1 HPV124	10	8.0	28	7.5	1.01	0.46 – 2.21	0.99	>0.999
Beta2 HPV23	12	9.6	26	7.0	1.34	0.64 – 2.81	0.44	>0.999
Beta2 HPV37	8	6.4	28	7.5	0.97	0.42 – 2.27	0.95	>0.999
Beta2 HPV38	24	19.2	57	15.3	1.28	0.75 – 2.18	0.37	>0.999
Beta2 HPV107	17	13.6	29	7.8	1.85	0.94 – 3.62	0.08	0.703
Gamma HPV Species†
Any Gamma HPV	53	42.4	125	33.6	1.38	0.89 – 2.13	0.15	0.924
Any Gamma7 HPV	20	16.0	49	13.2	1.11	0.62 – 2.01	0.72	>0.999
Any Gamma8 HPV	13	10.4	38	10.2	1.02	0.52 – 2.01	0.95	>0.999
Any Gamma10 HPV	13	10.4	28	7.5	1.33	0.66 – 2.71	0.42	>0.999
Any Gamma12 HPV	8	6.4	19	5.1	1.34	0.56 – 3.20	0.51	>0.999
Any Gamma15 HPV	13	10.4	28	7.5	1.39	0.66 – 2.89	0.39	>0.999

^†Beta and gamma HPV species and types presented have a prevalence of 5% or higher either in cases or controls

^*OR and 95% CI were estimated from conditional logistic regression models adjusted for smoking, alcohol consumption and study cohort.

^ξPermutated P-values were calculated to account for multiple comparisons (see methods)