Table 4.
Associations of beta and gamma HPVs species and types with risk of histological type of esophageal cancer
| 4A. Esophageal Squamous Cell Carcinoma (ESCC) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Beta HPV Species† | Cases (n=28) | Controls (n=83) | Adjusted Model* | Permutated Pξ |
||||
| N | % | N | % | OR* | 95% CI | P | ||
| Any Beta HPV | 14 | 50.0 | 41 | 49.4 | 1.05 | 0.37 – 2.97 | 0.93 | >0.999 |
| Any Beta1 HPV | 10 | 35.7 | 27 | 32.5 | 1.19 | 0.42 – 3.35 | 0.75 | >0.999 |
| Any Beta2 HPV | 11 | 39.3 | 33 | 39.8 | 0.99 | 0.36 – 2.72 | 0.99 | >0.999 |
| Any Beta3 HPV | 3 | 10.7 | 19 | 22.9 | 0.35 | 0.1 – 1.48 | 0.15 | 0.792 |
| Specific Beta HPV Types† | ||||||||
| Beta1 HPV5 | 5 | 17.9 | 10 | 12.1 | 1.56 | 0.44 – 5.53 | 0.49 | >0.999 |
| Beta1 HPV12 | 3 | 10.7 | 9 | 10.8 | 1.24 | 0.26 – 5.79 | 0.79 | >0.999 |
| Beta1 HPV20 | 3 | 10.7 | 8 | 9.6 | 1.10 | 0.25 – 4.81 | 0.89 | >0.999 |
| Beta1 HPV36 | 4 | 14.3 | 6 | 7.2 | 1.72 | 0.36 – 8.14 | 0.50 | >0.999 |
| Clade of Beta1 HPVs 5, 36, 47, & 143 | 6 | 21.4 | 12 | 14.5 | 1.31 | 0.39 – 4.39 | 0.66 | >0.999 |
| Beta2 HPV23 | 2 | 7.1 | 6 | 7.2 | 1.31 | 0.20 – 8.38 | 0.78 | >0.999 |
| Beta2 HPV38 | 4 | 14.3 | 16 | 19.3 | 0.62 | 0.18 – 2.11 | 0.45 | >0.999 |
| Gamma HPV Species† | ||||||||
| Any Gamma HPV | 12 | 42.9 | 26 | 31.3 | 1.31 | 0.51 – 3.31 | 0.57 | >0.999 |
| Any Gamma7 HPV | 3 | 10.7 | 6 | 7.2 | 0.81 | 0.15 – 4.48 | 0.81 | >0.999 |
| Any Gamma8 HPV | 3 | 10.7 | 9 | 10.8 | 0.61 | 0.12 – 3.11 | 0.55 | >0.999 |
| Any Gamma10 HPV | 4 | 14.3 | 8 | 9.6 | 1.46 | 0.37 – 5.82 | 0.59 | >0.999 |
| Any Gamma15 HPV | 3 | 10.7 | 8 | 9.6 | 1.22 | 0.29 – 5.14 | 0.79 | >0.999 |
| 4B. Esophageal Adenocarcinoma | ||||||||
|---|---|---|---|---|---|---|---|---|
| Beta HPV Species† | Cases (n=80) | Controls (n=239) | Adjusted Model* | Permutated Pξ |
||||
| N | % | N | % | OR* | 95% CI | p | ||
| Any Beta HPV | 56 | 70.0 | 134 | 56.1 | 1.84 | 1.05 – 3.23 | 0.04 | 0.199 |
| Any Beta1 HPV | 41 | 51.3 | 94 | 39.3 | 1.74 | 1.00 – 3.04 | 0.05 | 0.296 |
| Any Beta2 HPV | 42 | 52.5 | 105 | 43.9 | 1.34 | 0.80 – 2.25 | 0.27 | >0.999 |
| Any Beta3 HPV | 18 | 22.5 | 34 | 14.2 | 1.86 | 0.95 – 3.63 | 0.07 | 0.363 |
| Specific Beta HPV Types† | ||||||||
| Beta1 HPV5 | 14 | 17.5 | 27 | 11.3 | 1.78 | 0.85 – 3.72 | 0.13 | 0.605 |
| Beta1 HPV12 | 6 | 7.5 | 16 | 6.7 | 1.11 | 0.42 – 2.93 | 0.83 | >0.999 |
| Beta1 HPV20 | 14 | 17.5 | 31 | 13.0 | 1.42 | 0.70 – 2.91 | 0.33 | >0.999 |
| Beta1 HPV36 | 10 | 12.5 | 23 | 9.6 | 1.13 | 0.50 – 2.55 | 0.77 | >0.999 |
| Clade of Beta1 HPVs 5, 36, 47, & 143 | 17 | 21.3 | 39 | 16.3 | 1.36 | 0.71 – 2.58 | 0.35 | >0.999 |
| Beta1 HPV105 | 11 | 13.8 | 20 | 8.4 | 1.62 | 0.72 – 3.63 | 0.24 | >0.999 |
| Beta1 HPV124 | 7 | 8.8 | 20 | 8.4 | 1.06 | 0.42 – 2.67 | 0.90 | >0.999 |
| Beta2 HPV23 | 9 | 11.3 | 17 | 7.1 | 1.67 | 0.70 – 3.97 | 0.24 | >0.999 |
| Beta2 HPV37 | 8 | 10.0 | 21 | 8.8 | 1.21 | 0.49 – 2.97 | 0.68 | >0.999 |
| Beta2 HPV38 | 15 | 18.8 | 34 | 14.2 | 1.48 | 0.75 – 2.92 | 0.26 | >0.999 |
| Beta2 HPV107 | 10 | 12.5 | 19 | 8.0 | 1.69 | 0.72 – 3.98 | 0.23 | >0.999 |
| Gamma HPV Species† | ||||||||
| Any Gamma HPV | 32 | 40.0 | 77 | 32.2 | 1.53 | 0.86 – 2.70 | 0.15 | 0.668 |
| Any Gamma7 HPV | 13 | 16.3 | 34 | 14.2 | 1.12 | 0.54 – 2.34 | 0.76 | >0.999 |
| Any Gamma8 HPV | 4 | 5.0 | 21 | 8.8 | 0.43 | 0.14 – 1.36 | 0.15 | >0.999 |
| Any Gamma10 HPV | 7 | 8.8 | 17 | 7.1 | 1.38 | 0.52 – 3.66 | 0.52 | >0.999 |
| Any Gamma12 HPV | 7 | 8.8 | 13 | 5.4 | 1.92 | 0.72 – 5.14 | 0.19 | >0.999 |
| Any Gamma15 HPV | 8 | 10.0 | 14 | 5.9 | 1.93 | 0.69 – 5.42 | 0.21 | >0.999 |
†
Beta and gamma HPV species and types presented have a prevalence of 5% or higher either in cases or controls
*
OR and 95% CI were estimated from conditional logistic regression models adjusted for smoking, alcohol consumption, and study cohort
ξ
Permutated P-values were calculated to account for multiple comparisons (see methods)