Figure 4. Inhibition of rHBcAgc Formation by scFv e13 and Fab e21.

Negative-stain EM of (A) rHBcAgd, (B) rHBcAgc, (C) rHBcAgd-scFv e13, and (D) rHBcAgd-Fab e21. (A) Nonassembly conditions (pH 9.5), (B-D) capsid assembly conditions (pH 7.5 and 250 mM NaCl). Antibody fragments alone, not shown. All images are at the same magnification. Scale bar, 50 nm. See also Figure S7 and Figure S8.