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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Semin Cell Dev Biol. 2018 Apr 4;89:47–57. doi: 10.1016/j.semcdb.2018.03.020

Figure 3. Induction and inhibition of NET release in response to fungal pathogens based on morphology.

Figure 3

C. albicans, C. dubliniensis, and C. glabrata induce NET formation. Yeast forms of C. albicans can inhibit NET release through engagement of Dectin-1 and subsequent induction of phagocytosis. In addition, yeast efficiently scavenge ROS which is required for NET induction. The capsule of C. neoformans inhibits NET release. A. fumigatus hyphae and biofilms trigger NET release. However, A. fumigatus conidia inhibit formation and are engulfed by phagocytosis. Both conidia and yeast forms of P. braziliensis induce NETs.