Table 5.

Mutation results for patients treated at 75mg daily

Tumor type	PTEN loss	PIK3CA mutation	AKT mutation	BRAF mutation	KRAS mutation	NRAS mutation	PR or SD
Endometrium	Yes	Yes	No	Unk	Unk	Unk	SD
Endometrium	Yes	Yes	No	Unk	Unk	Unk
Endometrium	Yes	Yes	Unk	No	Unk	Yes	SD
Endometrium	Yes	No	No	Unk	Unk	Unk	SD
Endometrium	Yes	No	No	Unk	Unk	Unk	SD
Endometrium	Yes	No	No	Unk	Unk	Unk
Endometrium	Yes	No	Unk	No	No	No
Endometrium	No	Yes	No	Unk	Unk	Unk	PR
Endometrium	Unk	Yes	Unk	No	No	Unk
Endometrium	Unk	Yes	Unk	No	Yes	No
Prostate	Yes	No	Unk	Unk	Unk	Unk	SD
Prostate	Yes	No	Unk	Unk	Unk	Unk	SD
Prostate	Yes	No	Unk	Unk	Unk	Unk
Prostate	No	No	Unk	Unk	Unk	Unk	SD
Prostate	No	No	Unk	Unk	Unk	Unk
Prostate	No	No	Unk	Unk	Unk	Unk
Prostate	Unk	No	Unk	Unk	Unk	Unk
Prostate	Unk	No	Unk	Unk	Unk	Unk
Ovary	Yes	No	Unk	No	No	Unk	PR
Ovary	Yes	No	Unk	No	No	Unk
Ovary	No	No	Unk	No	No	Unk
Ovary	No	No	Unk	No	No	Unk
Ovary v unknown primary	Yes	No	Unk	No	Yes	Unk
Colon/rectum	Yes	Yes	No	No	No	Unk
Colon/rectum	Yes	No	Unk	Unk	Unk	Unk
Colon/rectum	Yes	No	Unk	No	Unk	Unk
Colon/rectum	No	Yes	Unk	No	No	Unk
Cervix	Yes	No	Unk	Unk	Unk	Unk
Cervix	Yes	No	Unk	No	No	No
Head/neck	Yes	No	Unk	Unk	Unk	Unk
Head/neck	Unk	Yes	Unk	No	No	No
Breast	No	No	No	Unk	Unk	Unk
Hepatocellular	Yes	No	Unk	Unk	Unk	Unk
Leiomyosarcoma	Yes	No	Unk	Unk	Unk	Unk

Abbreviation: Unk, unknown; PR, partial response; SD, stable disease >6 months