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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Neurosurg Anesthesiol. 2019 Apr;31(2):247–256. doi: 10.1097/ANA.0000000000000499

Figure 5. Frequency and severity of recurrent seizures in BCAA- and water-treated animals.

Figure 5

Figure 5

After 10 days of drinking either plain water or a solution of 4% BCAAs dissolved in water, rats were implanted with an osmotic pump through which MSO was chronically infused at a rate of 0.625 μg per hour in the right dentate gyrus. Rats were then subjected to 3 weeks of video-EEG analysis, whereby the frequency and severity (Racine scale 1–5) of seizures were recorded. (A) There were no differences in the total average number of seizures per day during weeks 1, 2, or 3 of EEG analysis. During week 2, there was a nonsignificant trend (p = 0.077) towards fewer seizures in rats who drank branched-chain amino acid solution. (B) There were no differences in the average number of non-convulsive (subclinical – Racine stage 2) or convulsive (Racine stage 3 – 5) seizures during weeks 1, 2, of 3 of EEG analysis. Data is presented as mean number of seizures per day ± SEM.