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. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: J Neurosurg Anesthesiol. 2019 Apr;31(2):247–256. doi: 10.1097/ANA.0000000000000499

(A) Section stained with NeuN demonstrating neurons within the dentate hilus (borders outlined with dashed lines) in a representative control and (B) branched-chain amino acid (BCAA) rat. The white arrows point to a stained neuron. (C) Rats in the branched-chain amino acid vs. control group had 36% fewer neurons in the dentate hilus of the hemisphere ipsilateral (p<0.0001) to the methionine sulfoximine infusion and 29% fewer neurons contralateral (p<0.001) to the infusion. Data is presented as mean number of cells per 100 mm³ ± SEM. ****p < 0.0001, ***p < 0.001

(A) Section stained with NeuN demonstrating neurons within the dentate hilus (borders outlined with dashed lines) in a representative control and (B) branched-chain amino acid (BCAA) rat. The white arrows point to a stained neuron. (C) Rats in the branched-chain amino acid vs. control group had 36% fewer neurons in the dentate hilus of the hemisphere ipsilateral (p<0.0001) to the methionine sulfoximine infusion and 29% fewer neurons contralateral (p<0.001) to the infusion. Data is presented as mean number of cells per 100 mm³ ± SEM. ****p < 0.0001, ***p < 0.001