Figure 1. Schematic representation of ALS-related genes and their modulatory effects on autophagy.

The spectrum of ALS-associated genes and their various modulatory effects upon autophagy entailing the stages of autophagy initiation, autophagosome maturation, and autophagosome-lysosome/endosome fusion are depicted herein. Proteins prone to aggregation are highlighted in yellow, those involved in autophagic initiation and autophagosome formation in red, those involved in endosome trafficking and the autophagosome-lysosome fusion in green, and those with less defined roles in autophagy are signified in white.