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. 2018 Oct 4;6(19):e13876. doi: 10.14814/phy2.13876

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Representative recording of type‐1 cell TASK channel activity over ~1.5 min of a cell‐attached patch recording demonstrating inhibition of channel activity by 400 nmol/L A1899. (B) Data from same recording over ~0.5 sec intervals under control conditions (i) and in the presence of A1899 (ii). (C) Concentration‐response relationship of effects of A1899 on type‐1 cell TASK channel activity (expressed as % inhibition in the presence of A1899 compared to control). Data are mean ± SEM (n = 4, 8 and 6 for 40, 400 and 4000 nmol/L concentrations of A1899, respectively). (D) Representative all‐points frequency histogram showing reduction of current at all levels corresponding to channel open states. Each bar represents a 0.1 pA bin width. Data were generated from analysis of 20 sec segments from cell‐attached recordings.