Table 1.

Important recent trials regarding hypofractionation in breast cancer

	START-A [4]			START-B [4]			Canadian Trial [7]
	CFRT	HFRT	p	CFRT	HFRT	p	CFRT	HFRT	p
Patients, n	749	737/750		1,105	1,110		612		622
Median follow-up, years	9.3			9.9			12.0
Daily RT dose, Gy	2	3.0/3.2		2	2.67		2	2.66
Total RT dose, Gy	50	39.0/41.6		50	40.05		50	42.5
Mean treatment time, days	35	35/35		35	21		35	22
10-year locoregional relapse, %	7.4	8.8/6.3	0.41/0.65	5.5	4.3	0.21	6.7	6.2	0.001a
10-year overall survival, %	80.2	79.7/81.6	0.69/0.74	80.8	84.1	0.042	84.4	84.6	0.79

^aFor non-inferiority.

CFRT = Conventional fractionated radiation therapy; HFRT = hypofractionated radiation therapy; RT = radiotherapy.