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. 2018 Oct 3;9:2041731418801103. doi: 10.1177/2041731418801103

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — IMS causes the production of inflammatory mediators, COX-2, IL-6, and PGE2 in PF-S and PF-C stem cells. Western blot shows that MMS does not cause significant changes of COX-1 expression in both PF-S and PF-C cells (a). However, IMS significantly enhances expression of COX-1 in PF-S and COX-2 expression in both types of cells (b). The IL-6 production in PF-S cells is seven times higher than that of PF-C cells (c). MMS does not change the IL-6 production significantly in both PF-S and PF-C cells compared to control groups. However, IMS significantly increases IL-6 production in both PF-S (2-fold) and PF-C cells (8-fold) compared to respective unstretched controls. Under IMS condition, PF-S cells have twice the amount of IL-6 compared to PF-C cells (c). PGE2 level in control PF-S cells is also much higher (5.6-fold) than PF-C cells (d). MMS does not change PGE2 production in both PF-S and PF-C cells; however, IMS significantly increases PGE2 production in both PF-S (2-fold) and PF-C cells (8-fold) compared to respective unstretched controls (d). *p < 0.05.