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Melanocortin receptors and ligand selectivity
| Melanocortin Receptor | POMC-Derived Peptides |
|---|---|
| MC1R | α-MSH = ACTH > β-MSH > γ-MSH |
| MC2R | ACTH only |
| MC3R | α-MSH = β-MSH = γ-MSH = ACTH |
| MC4R | α-MSH = ACTH > β-MSH > γ-MSH |
| MC5R | α-MSH > ACTH > β-MSH > δ-MSH |
MSH, melanocyte stimulating hormone; ACTH, adrenocorticotropic hormone.
