Fig. 1.

Global total Acat1 knockout mouse model (Acat1−/−), but not myeloid-specific Acat1 knockout mouse model (Acat1^−M/−M), increases hematopoietic recovery. On day 0, wild-type (WT), Acat1−/−, and Acat1^−M/−M mice were treated with 5-fluorouracil (5-FU; 200 mg/kg ip injection); the number of blood myeloid cells (CD11b⁺Gr1⁺) was measured at various time points as indicated. Eight-week-old mice with comparable numbers in male and female populations were used (n = 18–22 per group). Results reported are means ± SE. *P < 0.05; **P < 0.01.