Table 1.
Upregulated miRNAs in HCC
| MiRNA | Targets | Mechanisms | References |
|---|---|---|---|
| miR-10b | CSMD1 | Migration, invasion | 20 |
| miR-21 | CAMSAP1, DDX1, MARCKSL1 | No mentioned | 21 |
| miR-25 | RhoGDI1, TRAIL | EMT, apoptosis | 22, 23 |
| miR-32 | No mentioned | Prognostic marker | 24 |
| miR-92a | FBXW7 | Cell growth, prognostic marker | 25 |
| miR-96-5p | Caspase-9 | Apoptosis | 26 |
| miR-107 | Axin2, HMGA2, HMGCS2 | Proliferation, prognostic marker | 27-29 |
| miR-135a | FOXO1 | Migration, invasion | 30 |
| miR-155-5p | PTEN | Proliferation, apoptosis, invasion, migration | 31 |
| miR-181a | Atg5 | Autophagy | 32 |
| miR-182 | TP53INP1 | Drug resistance | 33 |
| miR-197 | CD82 | Migration, invasion | 34 |
| miR-203a-3p.1 | IL-24 | Cell growth, proliferation, metastasis | 35 |
| miR-210 | FGFRL1, YES1 | Metastasis, angiogenesis, proliferation | 36, 37 |
| miR-214-5p | WASL | Migration, invasion, EMT | 38 |
| miR-216a/217 | PTEN, SMAD7 | Drug resistance | 39 |
| miR-221 | No mentioned | Prognostic marker | 40 |
| miR-302d | TGFBR2 | Cell growth, apoptosis, migration | 41 |
| miR-331-3p | ING5 | Proliferation, apoptosis | 42 |
| miR-346 | FBXL2 | Proliferation, migration, invasion | 43 |
| miR-454 | CHD5 | Proliferation, EMT, prognostic marker | 44 |
| miR-487a | SPRED2, PIK3R1 | Proliferation, metastasis, prognostic marker | 45 |
| miR-765 | INPP4B | Proliferation | 46 |
| miR-873 | TSLC1 | Proliferation, migration, invasion | 47 |
| miR-892a | CD226 | Proliferation, invasion | 48 |
| miR-1246 | CADM1 | Migration, invasion, diagnostic and prognostic marker | 49 |
| miR-1249 | PTCH1 | Cell growth, migration, invasion | 50 |
| miR-1468 | CITED2, UPF1 | Proliferation, apoptosis | 51 |
| miR-3910 | MST1 | Cell growth, migration | 52 |
| miR-4417 | TRIM35 | Proliferation, apoptosis | 53 |