Table 2.
Downregulated miRNAs in HCC
MiRNA | Targets | Mechanisms | References |
---|---|---|---|
miR-7 | mTOR, TYRO3 | Autophagy, drug resistance | 54, 55 |
miR-7/21/107 | Maspin | Drug resistance, prognostic marker | 56 |
miR-26 | ULK1 | Autophagy | 57 |
miR-29a | CLDN1 | Proliferation, migration | 58 |
miR-30a-5p | AEG-1 | Cell growth, apoptosis | 59 |
miR-30e | MTA1 | EMT | 60 |
miR-31 | NDRG3 | Drug resistance | 61 |
miR-31-5p | SP1 | Proliferation, migration, invasion | 62 |
miR-33a | No mentioned | Prognostic marker | 63 |
miR-33a-5p | No mentioned | Drug resistance | 64 |
miR-33b | SALL4 | Proliferation, metastasis | 65 |
miR-98 | EZH2 | Proliferation | 66 |
miR-101 | Mcl-1, RAB5A, STMN1, ATG4D | Apoptosis, autophagy, diagnostic marker | 67-69 |
miR-105-1 | NCOA1 | Diagnostic and prognostic marker | 70 |
miR-122 | Snail1, Snail2, PKM2, DLX4 | EMT, proliferation, apoptosis, prognostic marker | 71-73 |
miR-124-3p | MAPK14, RELA, CDK2, CDK4, SP1 | No mentioned | 74 |
miR-126 | VEGF | Angiogenesis | 75 |
miR-137 | EZH2 | Proliferation, invasion | 76 |
miR-138 | Cyclin D3, SP1 | Prognosis marker, Proliferation, invasion, migration | 77, 78 |
miR-142 | THBS4, TGF-β | Migration, invasion, cell growth, metastasis | 79, 80 |
miR-142-3p | ATG5, ATG16L1, LDHA | Autophagy, drug resistance, proliferation | 81, 82 |
miR-143 | TLR2 | Proliferation, invasion | 83 |
miR-144 | ZFX | Proliferation, invasion, migration | 84 |
miR-146a | HAb18G | Metastasis, angiogenesis | 85 |
miR-152 | RTKN, DNMT1 | Cell growth | 86, 87 |
miR-186 | YAP1 | Migration, invasion, proliferation | 88 |
miR-187-3p | S100A4 | EMT | 89 |
miR-194 | MAP4K4 | Proliferation, diagnostic and prognostic marker | 90 |
miR-195 | Wnt3a, CBX4, FGF2, VEGFA | Proliferation, metastasis, angiogenesis | 91-93 |
miR-199 | RGS17 | Proliferation, migration, invasion | 94 |
miR-199a-3p | VEGFA, VEGFR1, VEGFR2, HGF, MMP2, YAP1 | Angiogenesis, proliferation, apoptosis | 95, 96 |
miR-199a-5p | CLTC | Cell growth | 97 |
miR-199b-5p | TGF-β1 | EMT | 98 |
miR-200a | CXCL1, GAB1 | EMT, invasion, migration | 99, 100 |
miR-203 | IL-1β, Snail1, Twist1 | Proliferation, metastasis | 101 |
miR-206 | CCND1, cMET, CDK6 | Proliferation, apoptosis | 102 |
miR-211 | SPARC | Proliferation, migration, invasion | 103 |
miR-212 | FOXM1 | Migration, cell growth | 104 |
miR-217 | MTDH | Proliferation, apoptosis, migration, invasion | 105 |
miR-223 | Rab1 | Proliferation, apoptosis | 106, 107 |
miR-296 | FGFR1 | Proliferation, apoptosis, prognostic marker | 108 |
miR-320a | c-Myc | Proliferation, invasion | 109 |
miR-337 | HMGA2 | Proliferation, apoptosis | 110 |
miR-338-3p | TAZ, MACC1, β-catenin, VEGF | Proliferation, migration, angiogenesis | 111, 112 |
miR-340 | JAK1 | Proliferation, invasion | 113 |
miR-345 | IRF1 | Metastasis, EMT | 114 |
miR-361-5p | VEGFA | Proliferation, invasion | 115 |
miR-365 | ADAM10 | Proliferation, metastasis | 116 |
miR-367-3p | MDM2 | Drug resistance | 117 |
miR-370 | PIM1 | Cell growth, invasion | 118 |
miR-375 | HMSN | Drug resistance | 119 |
miR-377 | Bcl-xL | Apoptosis | 120 |
miR-429 | RAB23 | Metastasis, EMT | 121 |
miR-451 | IL-6R | Angiogenesis | 122 |
miR-491-3p | ABCB1, Sp3 | Drug resistance | 123 |
miR-495 | IGF1R | Proliferation, invasion | 124 |
miR-497 | VEGFA, AEG-1 | Angiogenesis, metastasis | 125 |
miR-503 | No mentioned | Drug resistance | 126 |
miR-506 | ROCK1 | Proliferation, apoptosis | 127 |
miR-520f | TM4SF1 | Proliferation, invasion, migration | 128 |
miR-539 | FSCN1 | Migration, invasion, drug resistance | 129, 130 |
miR-542-3p | FZD7, Survivin | Proliferation | 131, 132 |
miR-613 | YWHAZ | Proliferation, invasion | 133 |
miR-634 | Rab1A, DHX33 | Cell growth, metastasis | 134 |
miR-638 | VEGF, SOX2 | Angiogenesis, invasion, EMT | 135, 136 |
miR-663a | HMGA2 | Proliferation, invasion | 137 |
miR-708 | SMDAD3 | Proliferation, migration, invasion | 138 |
miR-874 | DOR | Proliferation, metastasis | 139 |
miR-874-3p | PIN1 | Proliferation, apoptosis | 140 |
miR-876-5p | BCORL1 | Migration, invasion, EMT | 141 |
miR-940 | CXCR2 | Migration, invasion, prognostic marker | 142 |
miR-1207-5p | FASN | Cell growth, invasion | 143 |
miR-1271-5p | FOXK2 | Cell growth, prognosis marker | 144 |
miR-1299 | CDK6 | Proliferation | 145 |
miR-1301 | BCL9, β-catenin, VEGFA | Migration, invasion, angiogenesis | 146 |