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. 2018 Sep 8;9(19):3467–3478. doi: 10.7150/jca.26120

Table 2.

The Chi-square analysis of the clinicopathologic variables between the high-AAPR and low-AAPR groups in the training cohort.

Variables AAPR > 0.439, n (%) AAPR ≤ 0.439, n (%) P value
Total 117 (31.5) 255 (68.5)
Age, years ≤52 51 (43.6) 135 (52.9) 0.094
>52 66 (56.4) 120 (47.1)
Gender Male 110 (94.0) 238 (93.3) 0.803
Female 7 (6.0) 17 (6.7)
Ascites Yes 18 (15.4) 59 (23.1) 0.087
No 99 (84.6) 196 (76.9)
Laboratory parameters
AFP, ng/dL >400 47 (40.2) 126 (49.4) 0.097
≤400 70 (59.8) 129 (50.6)
BUN, mmol/L >8.9 3 (2.6) 8 (3.1) 0.762
≤8.9 114 (97.4) 247 (96.9)
ALB, g/L >36 107 (91.5) 139 (54.5) <0.001
≤36 10 (8.5) 116 (45.5)
ALP, U/L >200 0 (0) 51 (20.0) <0.001
≤200 117 (100.0) 204 (80.0)
Child-Pugh grade A 104 (88.9) 182 (71.4) <0.001
B 13 (11.1) 73 (28.6)
TNM stage III-IV 80 (68.4) 204 (80.0) 0.014
I-II 37 (31.6) 51 (20.0)
T category T3-4 79 (67.5) 202 (79.2) 0.015
T1-2 38 (32.5) 53 (20.8)
N category N0 105 (89.7) 196 (76.9) 0.003
N1 12 (10.3) 59 (23.1)
M category M0 112 (95.7) 230 (90.2) 0.069
M1 5 (4.3) 25 (9.8)
PVTT Yes 29 (24.8) 131 (51.4) <0.001
No 88 (75.2) 124 (48.6)
Survival rates (%) 3-months 99.1 87.5 <0.001
6-months 94.0 76.5 <0.001
1-year 85.5 60.8 <0.001
2-year 71.8 46.7 <0.001

HCC: hepatocellular carcinoma; TACE: transcatheter arterial chemoembolization; AFP: alpha fetoprotein; BUN: blood urea nitrogen; ALB: albumin; ALP: alkaline phosphatase; AAPR: albumin-to-alkaline phosphatase ratio; TNM: tumour-node-metastasis; PVTT: portal vein tumour thrombus.