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. 2018 Sep 8;9(19):3467–3478. doi: 10.7150/jca.26120

Table 3.

Univariate and multivariate analyses of the prognostic factors for overall survival in 372 HCC patients treated with TACE.

Variables Univariate Multivariate
Log-rank χ2 P value B SE HR 95% CI P value
Age, years (> 52/≤ 52) 1.068 0.301
Gender (male/female) 0.262 0.609
Ascites (yes/no) 1.196 0.274
Laboratory parameters
ALP, U/L (> 200/≤ 200) 2.898 0.089
ALB, g/L (> 36/≤ 36) 2.234 0.135
AFP, ng/dL (> 400/≤ 400) 4.947 0.026* 0.132 0.138 1.141 0.873 to 1.493 0.337
BUN, mmol/L (> 8.9/≤ 8.9) 1.967 0.161
T category (T1-2/T3-4) 7.412 0.006* -0.004 0.733 0.996 0.238 to 4.160 0.996
N category (N0/N1) 0.527 0.468
M category (M0/M1) 18.400 < 0.001* 0.650 0.228 1.916 1.229 to 2.987 0.004
TNM (I-II/III-IV) 7.670 0.006* 0.042 0.744 1.042 0.245 to 4.443 0.955
PVTT (yes/no) 33.300 < 0.001* 0.577 0.155 1.781 1.318 to 2.408 < 0.001
Child-Pugh grade (A/B) 0.612 0.434
AAPR (> 0.439/≤ 0.439) 17.336 < 0.001* -0.453 0.154 0.636 0.471 to 0.858 0.003

HCC: hepatocellular carcinoma; TACE: transcatheter arterial chemoembolization; ALP: alkaline phosphatase; ALB: albumin; AFP: alpha fetoprotein; BUN: blood urea nitrogen; TNM: tumour-node-metastasis; PVTT: portal vein tumour thrombus; AAPR: albumin-to-alkaline phosphatase ratio.

* Variables with a P value less than 0.05 were entered into multivariate analysis.