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. 2018 Sep 8;9(19):3467–3478. doi: 10.7150/jca.26120

Table 5.

Univariate and multivariate analyses of prognostic factors for overall survival in validation cohort II.

Variables Univariate Multivariate
Log-rank χ2 P value B SE HR 95% CI P value
Age, years (> 55/≤ 55) 0.665 0.415
Gender (male/female) 0.525 0.469
Ascites (yes/no) 0.026 0.872
Laboratory parameters
ALP, U/L (> 200/≤ 200) 7.166 0.007* 0.333 0.656 1.395 0.388 to 5.009 0.612
ALB, g/L (> 36/≤ 36) 3.871 0.049* -0.455 0.526 0.634 0.228 to 1.767 0.386
AFP, ng/dL (> 400/≤ 400) 0.089 0.765
BUN, mmol/L (> 8.9/≤ 8.9) 43.877 <0.001* 1.526 2.789 1.542 0.153 to 5.676 0.956
T category (T1-2/T3-4) 8.633 0.003* 0.538 2.561 1.713 0.257 to 6.556 0.999
N category (N0/N1) 1.699 0.192
M category (M0/M1) 0.483 0.487
TNM (Ⅰ-II/III-IV) 8.578 0.003* 2.248 2.562 1.467 0.434 to 5.235 0.999
PVTT (yes/no) 2.587 0.108
Child-Pugh grade (A/B) 0.043 0.837
AAPR (> 0.439/≤ 0.439) 17.336 < 0.001* -0.517 0.254 0.349 0.159 to 0.798 < 0.001

HCC: hepatocellular carcinoma; TACE: transcatheter arterial chemoembolization; ALP: alkaline phosphatase; ALB: albumin; AFP: alpha fetoprotein; BUN: blood urea nitrogen; TNM: tumour-node-metastasis; PVTT: portal vein tumour thrombus; AAPR: albumin-to-alkaline phosphatase ratio; NA: not applicable.

* Variables with a P value less than 0.05 were entered into multivariate analysis.