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Knockdown of PVT1 inhibits SCCHN tumorigenesis in vivo. Lentivirus mediated PVT1 shRNA1 (KD1) and control shRNA (Ctrl) were used to transfect Tu686 cells, which were then used to establish xenograft tumors. Final tumor images (A), tumor size (B), and tumor weight (C) were shown. (D) qPCR was used to emaxine the expression of E-cadherin and Vimentin. (E) Western blotting was applied to check the expression of total β-catenin protein. **, P < 0.01; ***, P < 0.001.
