Figure 4.
AAV Micro-dystrophin Gene Therapy Ameliorated Muscle Disease in the Murine and Canine DMD Models
(A) Systemic AAV micro-dystrophin injection improved skeletal muscle function in mdx mice. Treatment significantly improved specific tetanic force and resistance to eccentric contraction-induced force drop in the extensor digitorum longus muscle (see Shin et al.58 for details). Error bar, mean ± SEM. (B) Systemic AAV micro-dystrophin injection improved cardiac hemodynamics in mdx mice (see Bostick et al.59 for details). (C) AAV micro-dystrophin therapy improved histology (left) and reduced pathological muscle calcification (right) in the extensor carp ulnaris muscle in affected dogs (see Shin et al.58 for details).