TABLE 3.
Correlation of IHC markers with recurrent and nonrecurrent GCT
| Marker | H Score | n (%) | P | |
|---|---|---|---|---|
| Nonrecurrent (n = 71)* | Recurrent (n = 12) | |||
| Calretinin | Negative | 15 (21.1) | 1 (10.0) | 0.71 |
| Low: ≤50% | 25 (35.2) | 4 (40.0) | ||
| High: >50% | 31 (43.7) | 5 (50.0) | ||
| Inhibin | Negative | 41 (59.4) | 3 (30.0) | 0.02 |
| Low: ≤50% | 24 (34.8) | 4 (40.0) | ||
| High: >50% | 4 (5.8) | 3 (30.0) | ||
| Her2 | Negative | 71 (100.0) | 8 (80.0) | 0.014 |
| High≥80% | 0 (0.0) | 2 (20.0) | ||
| CD56 | Negative | 28 (38.4) | 0 (0.0) | 0.001 |
| Low: ≤80% | 17 (23.3) | 0 (0.0) | ||
| High: >80% | 28 (30.4) | 10 (100.0) | ||
| VEGF | Negative | 2 (2.8) | 0 (0.0) | 0.74 |
| Low: ≤80% | 2 (2.8) | 0 (0.0) | ||
| High: >80% | 67 (94.4) | 10 (100.0) | ||
| SMAD3 | Negative | 51 (72.9) | 0 (0.0) | 0.0001 |
| Low: ≤80% | 11 (15.7) | 2 (20.0) | ||
| High: >80% | 8 (11.4) | 8 (80.0) | ||
| GATA4 | Negative | 53 (74.6) | 6 (60.0) | 0.15 |
| Low: ≤80% | 15 (21.1) | 2 (20.0) | ||
| High: >80% | 3 (4.2) | 2 (20.0) | ||
*
Data is missing in some cases.
Bold values are statistically significant.
GCT indicates granulosa cell tumors; IHC, immunohistochemistry.