Table 2.

Clinicopathologic features of childhood enteropathies

	ABL	MVID	CTE	EED	EoGE
Underlying mechanism	MTP mutations	MyoVb mutations	EpCAM mutations	Neurogenin 3 mutation	Mixed T cell-IgE mediated immunity
Accompanying disease	Acanthocytosis Neurologic abnormalities Retinitis pigmentosa	None	Dysmorphic features including choanal, oesophageal or rectal atresia & autoimmune diseases	Insulin-dependent diabetes	Other allergic disorders
Biopsy features
Villus architecture	Normal	Variable	Variable	Variable	Villus blunting
Crypt architecture	Normal	Hyperplastic	Regenerative changes	Normal	Normal
Lamina propria inflammation	Absent	Minimal/absent	Variable	Absent	Predominantly eosinophilic
Intraepithelial lymphocytosis	Absent	Absent	Absent	Absent	Intraepithelial eosinophilia
Diagnostic histopathologic feature	Enterocyte vacuolization	Loss of brush border with apical vacuolization	Epithelial tufts	Lack of enteroendocrine cells on ChA	Extensive mucosal eosinophilia
Electron microscopy	Lipid vacuoles in enterocyte	Microvillus inclusion bodies	Not significant	Not significant	Not significant