Table S5: Example of annotation clustering from DAVID describing two enriched processes, Glutathione metabolism and transcriptional regulation.
Querying the Eurexpress list of genes using the annotation clustering tool in DAVID can define related processes. For example, the processes of Glutathione metabolism and transcriptional regulation were over represented in the Eurexpress gene list. DAVID was accessed on September 12, 2016.
| Category | Term | Count | PValue | List Total | Fold Enrichment |
|---|---|---|---|---|---|
| INTERPRO | IPR003081:Glutathione S-transferase, Mu class | 4 | 9.17E-05 | 275 | 40.58805195 |
| INTERPRO | IPR004046:Glutathione S-transferase, C-terminal | 5 | 0.001125184 | 275 | 10.76198347 |
| INTERPRO | IPR004045:Glutathione S-transferase, N-terminal | 5 | 0.001125184 | 275 | 10.76198347 |
| GOTERM_BP_DIRECT | GO:0018916~nitrobenzene metabolic process | 3 | 0.001306243 | 249 | 50.02710843 |
| GOTERM_MF_DIRECT | GO:0004364~glutathione transferase activity | 5 | 0.001350374 | 250 | 10.20451613 |
| GOTERM_MF_DIRECT | GO:0043295~glutathione binding | 4 | 0.001854759 | 250 | 15.817 |
| KEGG_PATHWAY | mmu00480:Glutathione metabolism | 6 | 0.002019562 | 128 | 6.569318182 |
| INTERPRO | IPR010987:Glutathione S-transferase, C-terminal-like | 5 | 0.003592444 | 275 | 7.892121212 |
| GOTERM_BP_DIRECT | GO:0042178~xenobiotic catabolic process | 3 | 0.004438218 | 249 | 28.5869191 |
| GOTERM_BP_DIRECT | GO:0006749~glutathione metabolic process | 5 | 0.004473115 | 249 | 7.411423472 |
| KEGG_PATHWAY | mmu00980:Metabolism of xenobiotics by cytochrome P450 | 5 | 0.006215115 | 128 | 6.690972222 |
| KEGG_PATHWAY | mmu00982:Drug metabolism - cytochrome P450 | 5 | 0.007815539 | 128 | 6.272786458 |
| UP_SEQ_FEATURE | domain:GST N-terminal | 4 | 0.008489343 | 255 | 9.420130719 |
| UP_SEQ_FEATURE | domain:GST C-terminal | 4 | 0.019907987 | 255 | 6.892778575 |
| KEGG_PATHWAY | mmu05204:Chemical carcinogenesis | 5 | 0.06493113 | 128 | 3.272758152 |
| INTERPRO | IPR012336:Thioredoxin-like fold | 5 | 0.122225117 | 275 | 2.630707071 |
| GOTERM_BP_DIRECT | GO:0008152~metabolic process | 10 | 0.291498366 | 249 | 1.378157257 |
| Annotation Cluster 2 | Enrichment Score: 2.202438644893318 | ||||
| Category | Term | Count | PValue | List Total | Fold Enrichment |
| UP_KEYWORDS | Nucleus | 86 | 2.44E-04 | 281 | 1.432714499 |
| UP_KEYWORDS | Transcription | 42 | 8.85E-04 | 281 | 1.694999913 |
| UP_KEYWORDS | Transcription regulation | 39 | 0.002932861 | 281 | 1.626656414 |
| GOTERM_BP_DIRECT | GO:0006351~transcription, DNA-templated | 40 | 0.012933994 | 249 | 1.466801787 |
| UP_KEYWORDS | DNA-binding | 33 | 0.014036324 | 281 | 1.541673065 |
| GOTERM_MF_DIRECT | GO:0003677~DNA binding | 37 | 0.041367714 | 250 | 1.372971261 |
| GOTERM_BP_DIRECT | GO:0006355~regulation of transcription, DNA-templated | 39 | 0.080401663 | 249 | 1.285281442 |