Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 3;18:943. doi: 10.1186/s12885-018-4816-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — EN2 protein expression in human ovarian tissue conveys poor prognosis. Enzymatic immunohistochemistry examples of normal kidney (a), normal ovary with surface epithelium (b) and ovarian adenocarcinoma stained for EN2 (c, e, g), or adjacent sections stained for H&E (d, f, h), at 10× magnification. The assigned staining intensity (1–3+) is indicated. EN2 staining (brown) is present in the cytoplasm, but not in the nucleus, and is not seen in the surrounding stroma. On the H&E stained sections, pink staining represents cytoplasm and blue staining represents the nucleus. (i) Survival curves for EN2 negative versus EN2 positive protein expression in high-grade serous ovarian tumours are shown (EN2 -ve = 0–4 IHC score; EN2 + ve = 5–12 IHC score). The median survival was significantly lower for all HGSOCs with EN2 + ve staining (10 months) versus those with EN2 –ve staining (17.5 months) (p = 0.0103)