Table 3.

Mayo imaging classification to identify rapidly progressive ADPKD: advantages and limitations

Criteria	Advantages	Limitations
Class 1C, 1D, or 1E	One-time measurement of htTKV	Lack of validation in nonwhite ethnic or racial populations
	Most helpful in patients with eGFR>60 ml/min per 1.73 m2	If MRI is contraindicated or not tolerated, it can be substituted by CT
	Confirmatory in patients with eGFR<60 ml/min per 1.73 m2 (if discordant, consider other disease process contributing to reduced eGFR)	Cost, but this is minor compared with the cost of tolvaptan and safety laboratory testing
	Most commonly in patients with a truncating PKD1 mutations (if discordant, it may be a clue to other factors contributing to disease severity)