Skip to main content
. 2018 Aug 24;29(10):2529–2545. doi: 10.1681/ASN.2018030324

Figure 1.

Figure 1.

Podocyte-specific induction of Krüppel-like factor 15 (KLF15) attenuates kidney injury and improves overall survival in Tg26 mice. Podocin-rtTA (PODTA), PODTA;TRE-KLF15, Tg26;PODTA, and Tg26;PODTA;TRE-KLF15 mice were treated with doxycycline at 4 weeks of age and euthanized at 12 weeks of age. (A) Nef and Vpr mRNA expressions were measured in glomerular fractions (n=8). ND, not determined. **P<0.01 versus PODTA and PODTA;TRE-KLF15 mice (Kruskal–Wallis test with Dunn post-test). (B) Albuminuria was measured at 4, 7, and 10 weeks of age in all four groups (n=8). *P<0.05 versus PODTA and PODTA;TRE-KLF15 mice (Kruskal–Wallis test with Dunn post-test); **P<0.01 versus all other groups (Kruskal–Wallis test with Dunn post-test). (C) Serum urea nitrogen and (D) serum creatinine were measured at 12 weeks of age in all four groups (n=8). **P<0.01 (Kruskal–Wallis test with Dunn post-test). (E) Survival curves for all four groups are shown until age 12 weeks old (log rank [Mantel–Cox] test). ***P<0.001.