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. 2018 Aug 24;29(10):2529–2545. doi: 10.1681/ASN.2018030324

Figure 2.

Figure 2.

Podocyte-specific induction of Krüppel-like factor 15 (KLF15) attenuates glomerulosclerosis and tubulointerstitial inflammation and fibrosis in Tg26 mice. Podocin-rtTA (PODTA), PODTA;TRE-KLF15, Tg26;PODTA, and Tg26;PODTA;TRE-KLF15 mice were treated with doxycycline at 4 weeks of age and euthanized at 12 weeks of age. All mice were euthanized and renal cortex fixed for histology. Periodic acid–Schiff and Masson Trichrome staining was performed to evaluate for tubulointerstitial changes. The representative images from four mice in each group are shown. Arrowheads show sclerotic glomeruli. *Tubulocystic dilation and proteinaceous casts; #interstitial inflammation and fibrosis.