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. 2018 Aug 24;29(10):2529–2545. doi: 10.1681/ASN.2018030324

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Figure 4. — Differentially expressed genes with enrichment analysis demonstrates upregulation of genes critical to maintaining podocyte differentiation and preventing cell detachment and effacement. Podocin-rtTA (PODTA) (lane 1), PODTA;TRE-KLF15 (lane 2), Tg26;PODTA (lane 3), and Tg26;PODTA;TRE-KLF15 (lane 4) mice were treated with doxycycline at 4 weeks of age and euthanized at 12 weeks of age. Glomeruli were isolated, and RNA was extracted for mRNA sequencing (n=3 per group). (A) Heat map analyses of all 600 transcripts differentially expressed between the Tg26;PODTA (lane 3) and Tg26;PODTA;TRE-KLF15 (lane 4) mice are shown in all four groups. (B) A combination of WikiPathway, KEGG Pathways, and NCI-Nature PID enrichment analyses of differentially expressed transcripts upregulated in the Tg26;PODTA;TRE-KLF15 (lane 4) compared with Tg26;PODTA (lane 3). (C) Gene ontology analysis of differentially expressed transcripts upregulated in the Tg26;PODTA;TRE-KLF15 (lane 4) compared with Tg26;PODTA (lane 3). (D) Heat map analysis of the average expression of differentially expressed transcripts related to podocyte-specific pathways between all four groups. (E) Heat map of the average expression of differentially expressed transcripts related to integrin signaling pathways between all four groups.