Figure 1.

Diabetic mice lacking a functional ACE N-domain display a more rapid natriuretic response compared with diabetic WT and CKO mice. Mice were challenged with an i.p. bolus of warmed saline equivalent to 10% of their body weight and placed in metabolic cages for hourly urine collection. Plots represent the (A) fraction of injected sodium and (C) volume excreted and the (B) accumulated excretion of sodium and (D) volume over a 5-hour collection period. Data are expressed as mean±SEM; n=5–8 per group. *P<0.05; **P<0.01 versus corresponding nondiabetic (Non-D); ^#P<0.05 diabetic WT versus diabetic NKO; ^##P<0.01 diabetic WT versus Non-D WT.