Table 1.

Phenotypic characteristics of WT, NKO, and CKO mice after 6 mo of diabetes induced by STZ

Parameter	WT		NKO		CKO
	Non-D	Diabetic	Non-D	Diabetic	Non-D	Diabetic
Blood glucose, mg/dl	129±10	545±16a	132±5	510±20a	133±4	524±16a
Body weight, g	29±2	26±1	28±1	26±2	29±1	26±1
Kidney-to-body weight, mg/g	5.5±0.3	7.0±0.5b	5.0±0.3	7.3±0.5b	5.3±0.2	7.5±0.4b
Systolic BP, mm Hg	102±6	104±4	105±7	101±4	106±7	96±6
Food intake, g/d	7.3±0.8	10.4±0.4b	6.7±0.6	10.7±0.6c	6.8±0.7	9.9±0.7b
Water intake, ml/d	2.2±0.9	20±1a	2.3±0.2	18±3a	2.4±0.4	18±2a
Urine excretion, ml/d	2.6±0.4	15±1a	2.3±0.4	14±2a	2.1±0.5	15±1c

Mice not treated with STZ (Non-D) were used as controls. Values represent mean±SEM.

^aP<0.001 versus corresponding Non-D group.

^bP<0.05 versus corresponding Non-D group.

^cP<0.01 versus corresponding Non-D group.