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. 2018 Oct 3;10:121. doi: 10.1186/s13148-018-0554-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — EZH2i-target genes promoters are methylated in EPZ-6438-resistant cells. a Molecular signature of EZH2i-target genes in six HMCLs (XG1, XG12, XG19, XG7, LP1, and XG25) was investigated using GSEA Database (all curated gene sets), and relevant pathways were presented (FDR q value ≤ 0.05). b Venn diagram presenting EZH2i-target genes compared to genes associated with H3K27me3 or H3K4me3 in XG7 HMCL. c Methylation status of CpGs overlapping with PRC2 target genes promoter region in EZH2i sensitive and resistant myeloma cell lines. d Heatmap presenting 111 EZH2i-target genes that are deregulated by decitabine using Affymetrix U133 plus 2.0 microarrays. e HMCLs were exposed to 1 μM of EPZ-6438 and/or 100 nM of decitabine. Cell viability was analyzed by trypan blue assay after 4, 8, and 11 days of treatment. Results are the percentage ± SD of viable myeloma cells of three independent experiments. * indicates a significant difference compared to control using a Wilcoxon test for pairs (P ≤ 0.05)