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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Trends Neurosci. 2018 Sep 25;41(10):701–711. doi: 10.1016/j.tins.2018.08.001

Figure 3. Interval selectivity simulated in a simple circuit with STP.

Figure 3.

A. Circuit composed of a single inhibitory (red circle) and excitatory (green triangle) neuron. Each synapse is endowed with STP [70]. Parameters used to simulate STP are shown, including the baseline release probability (U) and the time constants of facilitation (τf) and depression (τd). B. Excitatory and inhibitory responses to separate input spike intervals of 50, 100, and 200 ms are overlaid, illustrating short-term facilitation. C. The weights of the Input→Ex synapse (x-axis) and Input →Inh synapse (y-axis) are varied, and the interval selectivity at each point is examined. The color in each region indicates the responsiveness of the Ex unit to one or more of the input intervals. Black areas represent regimes in which the Ex unit fired to the first pulse only, or did not fire at all. D. Voltage traces of the Ex and Inh units during simulations with synaptic weights that resulted in a 100 ms interval detector (dotted rectangle in C). Based on [62].