Table 3.

Associations of potential baseline covariates with CRPC and OS

Covariates	CRPC, HR (95%CI)	P-value	OS, HR (95%CI)	P-value
Gleason score = 7 vs. ≤ 6 (ref)	0.9 (0.67 – 1.22)	0.508	0.85 (0.58 – 1.24)	0.398
Gleason score ≥ 8 vs. ≤ 6 (ref)	1.25 (0.96 – 1.63)	0.093	1.26 (0.91 – 1.74)	0.166
Median PSA (one log10 unit change)	1.33 (1.19 – 1.48)	< 0.001	1.23 (1.09 – 1.4)	0.001
Median Age > 62 vs. ≤ 62 years (ref)	1.04 (0.85 – 1.26)	0.721	1.19 (0.94 – 1.49)	0.142
ECOG PS ≥ 1 vs. = 0 (ref)	1.22 (0.89 – 1.67)	0.217	1.23 (0.86 – 1.77)	0.257
Pain vs. No pain (ref)	1.47 (1.17 – 1.86)	0.001	1.56 (1.19 – 2.04)	0.001
Year of diagnosis < 2004 vs. > 2009 (ref)	0.49 (0.32 – 0.73)	< 0.001	0.74 (0.4 – 1.37)	0.337
Year of diagnosis 2004 – 2009 vs. > 2009 (ref)	0.92 (0.62 – 1.38)	0.694	1.32 (0.71 – 2.44)	0.377
Extent of disease Bone plus/minus node vs. Node only (ref)	1.28 (1 – 1.65)	0.048	1.58 (1.14 – 2.19)	0.006
Extent of disease Viscera plus any vs. Node only (ref)	0.92 (0.59 – 1.45)	0.722	1.12 (0.63 – 2)	0.698

Trend-test = test of trend effect (Bone only vs. Node only vs. Bone plus node vs. Viscera plus any)

CRPC = castration-resistant prostate cancer; OS = overall survival; ref = reference