Table 3.

Characteristics of Pediatric ALL Patients According to miRNA-128 and Let-7b Expression

	miRNA-128		P-value	Let-7b		P-value
	Over expression	Under expression		Over expression	Under expression
	(n=47)	(n=9)		(n=37)	(n=33)
Age			0.658			0.9
< 2 years	8 (17)**	1 (11.1)**		5 (15.2)**	6 (16.2)**
≥ 2 years	39 (63)**	8 (88.9)**		28 (84.8)**	31 (83.8)**
Sex			1
Male	26 (55.6)**	5 (55.6)**		15 (40.5)**	22 (59.5)**	0.241
Female	21 (44.7)**	4 (44.4)**		18 (54.5)**	15 (40.5)**
Hepatomegaly	26 (55.3)**	6 (66.7)**	0.529	22 (66.7)**	20 (54)**	0.282
Splenomegaly	24 (51.1)**	6 (66.7)**	0.481	18 (54.5)**	23 (62.2)**	0.518
Lymphadenopathy	25 (53.2)**	6 (66.7)**	0.716	17 (51.5)**	20 (54)**	0.832
Total leukocytic count x 109/L			0.073			0.638
< 50 X 109/L	35 (74.5)**	4 (44.4)**		24 (72.7)**	25 (67.6)**
≥ 50 X 109/L	12 (25.5)**	5 (55.6)**		9 (27.3)**	12 (32.4)**
Hemoglobin gm/dl			0.246			0.348
<7 gm/dl	14 (29.8)**	1 (6.7)**		9 (27.3)**	14 (37.8)**
≥7 gm/dl	33 (70.2)**	8 (19.5)**		24 (72.7)**	23 (62.2)**
Platelet x 109/L			0.482			0.937
<100	37 (78.8)**	8 (17.8)**		27 (81.8)**	30 (81.1)**
≥100	10 (21.3)**	1 (9.1)**		6 (18.2)**	7 (18.9)**
Peripheral blood blasts	50.1±32.8*	69.8±36.4*	0.17	46.9±35.7*	60.9±30.2*	0.115
Bone marrow blasts	87.6±10.9*	90.9±5.6*	0.63	85.4±14.6*	89.0±10.0*	0.244
Bone marrow cellularity			0.834			0.12
Normocellular versus hypocellular	12 (25.5)**	2 (22.2)**		10 (27)**	4 (12.1)**
Hypercellular	35 (74.5)**	7 (77.8)**		27 (73)**	29 (87.9)**
Immunophenotyping			0.259			0.937
B-ALL	39 (83)**	6 (66.7)**		27 (81.8)**	30 (81.0)**
T-ALL	8 (17)**	3 933.3)**		6 (18.2)**	7 (19.0)**
CD34			0.719			0.937
Positive	4 (44.4)**	26 (55.3)**		15 (45.5)**	16 (43.2)**
Negative	5 (55.6)**	21 (44.7)**		18 (54.5)**	21 (56.8)**
Cytogenetics
Hyperdiploidy	5 (10.5)**	0	no	1 (3)**	4 (10.8)**	0.36
t (1;19)	1 (2.1)**	0	no	0	1 (2.1)**	no
t (9;22)	3 (6.4)**	2 (22.2)**	0.178	5 (15.2)**	0	0.02
t (12;21)	3 (6.4)**	0	no	1 (3)**	2 (5.4)**	no

^*Mean ± SD;

^**Number (%)