Table 1.

Patients’ characteristics and previous treatment and status of disease.

		Other malignant CNS tumor
	Ependymoma	High grade glioma	Low grade glioma	Other	Total
	(n = 8)	(n = 5)	(n = 10∗)	(n = 4)	(n = 19)
Age at inclusion	8.5 [5–13]	7.5 [4–20]	9.3 [4–15]	13.0 [11–18]	10.0 [4–20]
Sex (% of female)	1 (13%)	1 (20%)	7 (70%)	3 (75%)	11 (58%)
NF-1 status			1 (10%)		1 (5%)
Patients with metastases				1 (25%)	1 (5%)
Anterior surgery or radiotherapy
Only surgery	4 (50%)	1 (20%)	8 (80%)	2 (50%)	11 (58%)
Only radiotherapy		3 (60%)			3 (16%)
Surgery & radiotherapy	4 (50%)	1 (20%)	2 (20%)	2 (50%)	5 (26%)
Nr of previous lines of chemotherapy
0	2 (25%)
1	2 (25%)	3 (60%)		1 (25%)	4 (21%)
2	1 (13%)	1 (20%)	3 (30%)		4 (21%)
3	1 (13%)		1 (10%)		1 (5%)
>3	2 (25%)	1 (20%)	6 (60%)	3 (75%)	10 (53%)
Patients with previous vinca alkaloid			9 (90%)	2 (50%)	11 (58%)

Data are median [range] and n(%) of patients. Nr, Number. ^∗Eleven patients with LGG included with one patient not assessable at two cycles.