Fig. 14. Lifespan of C. elegans mutants treated with EISO, α- and β-santalol. Survival curves of (A) daf-2(e1370) (B) daf-16(mgDf50) (C) akt-1(ok525) (D) isp-1(qm150) (E) clk-1(e2519) (F) mev-1(kn1) (G) lin-45(n2520) (H) mek-2(n1989) and (I) mpk-1(ku1) mutant strains treated with 6-OHDA and 6-OHDA/EISO, α- or β-santalol till their end of life. The survival curves were plotted using Kaplan–Meier survival analysis and significance levels were estimated by long-rank test in Medcalc statistical software v.14. The representative Kaplan–Meier survival curves from three independent runs were presented. Statistical details of these experiments are summarized in ESI Table 7.†.