Fig. 18. Lifespan analysis and ROS accumulation in wdr-23(tm1817) loss-of-function worms exposed to 6-OHDA and 6-OHDA/EISO, α- and β-santalol. (A) Lifespan of wdr-23(tm1817). Survival curves were plotted using Kaplan–Meier survival assay and p value was calculated by log-rank rest. Three biological replicates were performed. Statistical details of this experiment are summarized in ESI Table 7.† (B) Graph depicts the intracellular generation of ROS in wdr-23(tm1817) mutant after treated with 6-OHDA or 6-OHDA/EISO, α- and β-santalol. Data were acquired from three independent biological experiments and presented as mean ± SEM, the probability levels of p < 0.05 were considered as statistically significant. **p < 0.01 and ns, not significant.