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. 2018 Oct 2;8(59):33753–33774. doi: 10.1039/c8ra05195j

Fig. 20. The proposed neuroprotective and geroprotective mechanism of EISO and its active components on C. elegans. EISO and santalol isomers likely acted through AKT-1 and ERK-MAPK mediated SKN-1 dependent pathway, which transactivates the stress-responsive genes gcs-1 and gst-4 that enhanced the tolerance to stress and extend the mean lifespan. The direct antioxidant activity, α-synuclein inhibitory potential, antiapoptotic activity, and CLK-1 dependency of EISO, α- and β-santalol can also contribute for the reduction of neurodegeneration and longevity extension in C. elegans.

Fig. 20