Lifespan analysis of N2 worms. EISO, α- and β-santalol treatment reduced the senescence induced by 6-OHDA in C. elegans. The mean lifespan was calculated as the average number of days animal survived in tested pharmacological dose(s) and analyzed using log-rank test. For the analysis of statistical significance, 6-OHDA alone treated group was compared with untreated control, and 6-OHDA/EISO, α- or β-santalol treated groups were compared with 6-OHDA alone treated group.

Genotype	Treatment	Mean survival (mean ± SEM)	Maximum lifespan (days)	Sample size (N)	% change	p value
N2	Control	12.156 ± 0.357	20	109
	6-OHDA	8.047 ± 0.347	13	92	(−) 33.80	<0.0001
	6-OHDA/EISO	15.443 ± 0.411	25	103	(+) 27.04	<0.0001
	6-OHDA/α-santalol	13.388 ± 0.456	22	108	(+) 10.13	<0.0001
	6-OHDA/β-santalol	16.183 ± 0.375	26	110	(+) 33.13	<0.0001