Figure 1.
CLDN6 expression level in EC was significantly upregulated.
Notes: (A) CLDN6 expression level of patients with EC (n=552) and controls (n=35) from the TCGA database was analyzed. (B) Relative expression levels of CLDN6 in EC tissues (n=82) relative to corresponding ANT tissues (n=82). CLDN6 expression was examined using PCR and normalized to GAPDH. (C) Relative expression levels of CLDN6 in EC cell line HEC-1-B relative to corresponding control cell. CLDN6 expression was examined using qRT-PCR and normalized to GAPDH. **P<0.001.
Abbreviations: UCEC, Uterine Corpus Endometrial Carcinoma; ANT, adjacent non-tumorous; CLDN6, claudin-6; EC, endometrial carcinoma; ESC, endometrial cells; TCGA, The Cancer Genome Atlas.