Table 2. Lifetime incidence and relative risk of infectious and chronic conditions among mothers in the ALSPAC cohort according to dichotomized FUT2 secretor status.
| Condition * |
FUT2 Secretor Status
(rs601338 genotype) |
Relative Risk
Non-Secretors vs. Secretors |
||||
|---|---|---|---|---|---|---|
| Non-Secretors
(AA) |
Secretors
(GA or GG) |
P value | ||||
| N=1920 | N=5662 | |||||
| cases | (%) | cases | (%) | RR (95% CI) | ||
| Infections | ||||||
| measles | 1458 | (75.9) | 4076 | (72.0) | 1.05 (1.02, 1.09) | 0.0008 |
| mumps | 1299 | (67.7) | 2734 | (48.3) | 1.40 (1.34, 1.46) | <0.0001 |
| chicken pox | 1656 | (86.3) | 4925 | (87.0) | 0.99 (0.97, 1.01) | 0.41 |
| whooping cough | 222 | (11.6) | 638 | (11.3) | 1.03 (0.89, 1.18) | 0.73 |
| cold sores | 843 | (43.9) | 2458 | (43.4) | 1.01 (0.95, 1.07) | 0.71 |
| meningitis | 15 | (0.8) | 61 | (1.1) | 0.73 (0.41, 1.27) | 0.26 |
| genital herpes | 45 | (2.3) | 108 | (1.9) | 1.23 (0.87, 1.73) | 0.24 |
| gonorrhea | 29 | (1.5) | 70 | (1.2) | 1.22 (0.80, 1.88) | 0.36 |
| urinary infection | 1095 | (57.0) | 3085 | (54.5) | 1.05 (1.00, 1.10) | 0.05 |
| Chronic conditions | ||||||
| kidney disease | 103 | (5.4) | 218 | (3.9) | 1.39 (1.11, 1.75) | 0.004 |
| hypertension | 272 | (14.2) | 804 | (14.2) | 1.00 (0.88, 1.13) | 0.94 |
| diabetes | 23 | (1.2) | 55 | (1.0) | 1.23 (0.76, 2.00) | 0.40 |
| rheumatism | 93 | (4.8) | 230 | (4.1) | 1.19 (0.94, 1.51) | 0.14 |
| arthritis | 77 | (4.0) | 188 | (3.3) | 1.21 (0.93, 1.57) | 0.15 |
| psoriasis | 59 | (3.1) | 213 | (3.8) | 0.82 (0.62, 1.08) | 0.16 |
| hay fever | 573 | (29.8) | 1742 | (30.8) | 0.97 (0.90, 1.05) | 0.45 |
| asthma | 215 | (11.2) | 652 | (11.5) | 0.97 (0.84, 1.12) | 0.71 |
| eczema | 469 | (24.4) | 1271 | (22.4) | 1.09 (0.99, 1.19) | 0.07 |
| any allergies | 837 | (43.6) | 2412 | (42.6) | 1.02 (0.97, 1.09) | 0.42 |
AA, homozygous for non-secretor alleles; GG, homozygous for secretor alleles; GA, heterozygous; ALSPAC, Avon Longitudinal Study of Parents and Children; RR, relative risk; CI, confidence interval. *Self-reported during pregnancy: "Have you ever had…?"