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Spot and mapping EDS analyses of different tissue regions of a group-1 patient in an SEM image: A, B SEM images with marked analysis positions 1–8 (elemental compositions shown in Table 2); C Spectra for the mapping analysis of the area of a particle 1; D Spectra for the mapping analysis of the surrounding fibrillar tissue area 2; E Spectra for the spot analysis of the particle at position 5
