Fig. 5.

Regulation of cytokine expression by combination treatment. EAE mice were sacrificed on day 30 after immunization. Splenocytes from each treatment group were stimulated with MOG (10 μg/mL) for 7 days. Cell culture supernatants from the splenocytes were examined by ELISA for A Pro-inflammatory (IFN-γ, TNF-α, IL-17) and B Anti-inflammatory (IL-4, IL-10) cytokines. Columns, mean; bars, SD. * p < 0.05, ** p < 0.01 compared to PBS treatment group; ^## p < 0.01 compared to MP treatment group; ^& p < 0.05, ^&& p < 0.01 compared to BM-MSCs treatment group; One-way ANOVA with LSD post hoc test. The results are representative of 3 independent experiments