Fig. 1.
Diagrammatic representation showing the in vivo experimental design in knee joints of NZW rabbits of full thickness surgical ablation of the tibial articular surface. A Control rabbit that received no treatment; B BM-MSCs (1 × 106 cells) + Hyalofast™; C cartilage pellet (CP) + Hyalofast™; and D BM-MSCs (1 × 106 cells) + CP + Hyalofast™. A, B showed partial to moderate filling with persistence of the surgical defect. C, D showed good tissue regeneration with near complete filling of the surgical defect. *NZW: New Zealand white, BM-MSCs: bone marrow mesenchymal stem cells