Fig. 4.
Representative toluidine blue histological images of the regenerated cartilage tissue following treatment with Hyalofast™ and/or BM-MSCs/Cartilage pellet in NZW rabbits with full thickness surgical ablation of the medial tibial articular surface. A Control rabbit that received no treatment; B rabbit treated with BM-MSCs (1 × 106 cells) + Hyalofast™; C rabbit treated with cartilage pellet (CP) + Hyalofast™ and D rabbit treated with BM-MSCs (1 × 106 cells) + CP + Hyalofast™. A, B showed weak to absent cartilage matrix staining. C, D showed intense cartilage matrix staining and presence of superficial, mid and deep zones indicating good cartilage regeneration. *BM-MSCs: bone marrow mesenchymal stem cells, NZW: New Zealand white