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. 2018 Sep 14;15(5):575–590. doi: 10.1007/s13770-018-0159-1

Table 1.

Biopolymers preparation, gelation method and their tissue engineering applications

Natural polymer Chemical structure Gelation method Types of encapsulation cells Tissue engineering applications References
Cellulose graphic file with name 13770_2018_159_Figa_HTML.gif Thermal cross-linking Cartilage cells Wound healing, drug delivery [12, 18, 38]
Chitosan graphic file with name 13770_2018_159_Figb_HTML.gif Free radical polymerization/chemical/Michael-type addition/thermal cross-linking and pH-induced cross-linking Human MSCs, chondrocytes Encapsulate hepatocytes, orthopedic scaffolds [17, 21–23, 41]
Collagen graphic file with name 13770_2018_159_Figc_HTML.gif Thermal cross-linking, chemical cross-linking Human MSCs, chondrocytes, cardiomyocytes, osteoblast Wound healing, promote blood coagulation, the scaffolds for cell [24, 27, 35]
Hyaluronic acid graphic file with name 13770_2018_159_Figd_HTML.gif Free radical polymerization, Michael-type addition Human MSCs, chondrocytes, fibroblast Cartilage regeneration, wound healing [15, 17, 23, 30]
Alginate graphic file with name 13770_2018_159_Fige_HTML.gif Ionic interaction, free radical polymerization Human MSCs, hepatocytes Wound healing, cartilage regeneration [5, 16, 35, 38–40]
Gelatin graphic file with name 13770_2018_159_Figf_HTML.gif Heating/cooling polymer solution solid state redaction Human MSCs Support cells for orthopedic applications [21, 29, 42]