Table 2. Cox proportional hazards model for TILs and covariables.

	OS				DSS				MFS
	Crude		Adjusted		Crude		Adjusted		Crude		Adjusted
Variable	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
TILS
Abs/Non brisk	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Brisk	0.58**	0.39 to 0.86	0.85	0.56 to 1.27	0.43*	0.22 to 0.83	0.58	0.29 to 1.14	0.37***	0.21 to 0.65	0.44**	0.25 to 0.77
Regression
Absent	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Present	0.55**	0.35 to 0.87	0.65	0.41 to 1.03	0.21**	0.07 to 0.56	0.31*	0.11 to 0.86	0.25***	0.12 to 0.51	0.36**	0.17 to 0.76
Age (years)	1.06***	1.05 to 1.08	1.06***	1.04 to 1.07	1.02**	1.01 to 1.04	1.01	0.99 to 1.03	1.02***	1.01 to 1.03	1	0.99 to 1.01
Sex
Female	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Male	1.79***	1.32 to 2.43	1.63**	1.17 to 2.26	1.66*	1.06 to 2.61	1.48	0.91 to 2.42	1.49*	1.04 to 2.15	1.52*	1.02 to 2.26
Site
Central	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Peripheral	0.67*	0.49 to 0.91	0.82	0.59 to 1.15	0.71	0.45 to 1.12	0.89	0.55 to 1.46	0.89	0.62 to 1.28	0.95	0.63 to 1.41
Breslow	1.14***	1.11 to 1.16	1.05*	1.00 to 1.09	1.15***	1.12 to 1.19	1.05	0.98 to 1.12	1.13***	1.11 to 1.16	1.07***	1.03 to 1.12
Mitotic rate	1.08***	1.06 to 1.10	1.03**	1.01 to 1.05	1.10***	1.08 to 1.12	1.05***	1.02 to 1.08	1.13***	1.11 to 1.15	1.08***	1.06 to 1.11
Ulcer
Absent	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Present	4.83***	3.53 to 6.61	2.42***	1.67 to 3.50	6.98***	4.43 to 11.00	3.25***	1.88 to 5.62	5.90***	4.08 to 8.55	2.18**	1.36 to 3.49
Microsatellites
Absent	1	ref	1	ref	1	ref	1	ref	1	ref	1	ref
Present	5.28***	2.47 to 11.28	1.19	0.53 to 2.70	3.11	0.76 to 12.71	0.48	0.11 to 2.10	6.74***	2.74 to 16.58	0.95	0.35 to 2.56

OS, overall survival; DSS, disease-specific survival; MFS, metastasis-free survival; TILs, tumour-infiltrating lymphocytes; HR, hazard ratio.

* p < 0.05; ** p < 0.01; *** p< 0.001