Table 3. Cox proportional hazards model for TIL percentage score and covariables.

	OS		DSS		MFS
Variable	Adjusted HR	95% CI	Adjusted HR	95% CI	Adjusted HR	95% CI
TILs % tertile
Lower tertile	1	ref	1	ref	1	ref
Mid/upper tertile	0.55 ***	0.38 to 0.78	0.25 ***	0.14 to 0.44	0.32 ***	0.21 to 0.51
Regression
Absent	1	ref	1	ref	1	ref
Present	0.73	0.46 to 1.16	0.44	0.16 to 1.26	0.47 *	0.22 to 0.99
Age (years)	1.05 ***	1.04 to 1.07	1.01	1.00 to 1.03	1.01	0.99 to 1.02
Sex
Female	1	ref	1	ref	1	ref
Male	1.71 **	1.23 to 2.39	1.65 *	1.01 to 2.69	1.64 *	1.10 to 2.44
Site
Central	1	ref	1	ref	1	ref
Peripheral	0.8	0.57 to 1.11	0.82	0.50 to 1.35	0.9	0.60 to 1.34
Breslow	1.03	0.99 to 1.08	1.02	0.95 to 1.10	1.06 *	1.01 to 1.10
Mitotic rate	1.02 *	1.00 to 1.05	1.04 **	1.01 to 1.07	1.07 ***	1.04 to 1.10
Ulcer
Absent	1	ref	1	ref	1	ref
Present	2.20 ***	1.51 to 3.20	2.62 ***	1.51 to 4.54	1.73 *	1.08 to 2.77
Microsatellites
Absent	1	ref	1	ref	1	ref
Present	1.05	0.46 to 2.40	0.41	0.09 to 1.82	0.99	0.36 to 2.72

OS, overall survival; DSS, disease-specific survival; MFS, metastasis-free survival; TILs, tumour-infiltrating lymphocytes; HR, hazard ratio.

* p < 0.05; ** p < 0.01; *** p< 0.001